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Updated: Apr 27, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin
Lun-Qing Wang1, Gang Chen1, Xiang-Yan Liu1
1Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
Abstract:
microRNAs play important roles in numerous biological processes, including tumorigenesis, by modulating critical gene transcripts. In the present study, the role of microRNA‑802 (miR‑802) in lung cancer was investigated. The results of the quantitative polymerase chain reaction revealed that expression levels of miR‑802 were significantly upregulated in lung cancer tissues. In vitro experiments demonstrated that miR‑802 promoted cell proliferation in A549, NCI‑H358 and NCI‑H1299 cells. Furthermore, it was indicated that miR‑802 promoted the proliferation of lung carcinoma by targeting the tumor suppressor menin. Therefore, these results suggest a previously unknown miR‑802/menin molecular network controlling lung carcinoma development.
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