Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical analysis of fever interval data.

C J Stok1, J W van der Meer, A C Kruseman

  • 1Department of Medical Informatics, Leiden University, The Netherlands.

European Journal of Clinical Investigation
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo efficacy of trovafloxacin against Bacteroides fragilis in mixed infection with either Escherichia coli or a vancomycin-resistant strain of Enterococcus faecium in an established-abscess murine model.

Antimicrobial agents and chemotherapy·2001
Same author

[What is the diagnosis and therapy in a chronic Mycoplasma pneumoniae infection?].

Nederlands tijdschrift voor geneeskunde·2001
Same author

Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial.

Lancet (London, England)·2001
Same author

Natural course of symptoms in Cambodia veterans: a follow-up study.

Psychological medicine·2001
Same author

Familial periodic fever and amyloidosis due to a new mutation in the TNFRSF1A gene.

The American journal of medicine·2001
Same author

[From gene to disease; tumor necrosis factor receptor and a syndrome of familial periodic fever].

Nederlands tijdschrift voor geneeskunde·2001
Same journal

Pacemaker Status and 5-Year Mortality After TAVI: A Sex-Specific Analysis.

European journal of clinical investigation·2026
Same journal

Causal Effects of Time-Varying Treatments: The G-Formula.

European journal of clinical investigation·2026
Same journal

Improving Scientific Research: Renegotiated Principles of Science, Proposals, Failures, and Successes.

European journal of clinical investigation·2026
Same journal

Beta-Blockers After Myocardial Infarction With Preserved and Mildly Reduced Ejection Fraction: A Meta-Analysis With Trial Sequential Analysis.

European journal of clinical investigation·2026
Same journal

Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.

European journal of clinical investigation·2026
Same journal

Circulating Human Epididymis Protein 4 Predicts 10-Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease.

European journal of clinical investigation·2026
See all related articles

Statistical analysis of fever intervals can reveal hidden periodicities in periodic fever syndromes. This approach helps in assessing complex fever patterns that lack clear fixed intervals, aiding in diagnosis.

Area of Science:

  • Medical statistics
  • Rheumatology
  • Computational biology

Background:

  • Periodic fever syndromes often lack fixed periodicity, making traditional statistical measures like mean and standard deviation insufficient for analysis.
  • Fever interval data can be modeled as a random point process, allowing for advanced statistical techniques to detect underlying patterns.
  • The renewal density function and its Fourier transform are key statistical tools for uncovering hidden periodicities in biological data.

Observation:

  • The study investigated fever interval data from three patients diagnosed with periodic fever syndromes.
  • One patient with hypothalamic periodic fever exhibited a distinct 30-day periodicity.
  • A patient with hyperimmunoglobulinaemia D and periodic fever showed a correlation between fever episodes and menstruation.

Related Experiment Videos

Findings:

  • The renewal density function was estimated and evaluated to analyze fever interval data.
  • A 30-day periodicity was identified in a patient with hypothalamic periodic fever.
  • Irregular fever patterns without discernible periodicity were observed in a patient with Familial Hibernian Fever-like syndrome.

Implications:

  • Computerized analysis of fever intervals offers a valuable method for assessing and differentiating various periodic fever syndromes.
  • This statistical approach can aid in the diagnosis and understanding of complex, non-fixed periodicity fever patterns.
  • The findings suggest that advanced statistical modeling can improve the characterization of rare fever disorders.