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Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD
İbrahim Fatih Karababa1, Sermin Nur Savas2, Sehabettin Selek3
11 Harran University, Sanliurfa, Turkey.
Insights
Adult ADHD patients show lower plasma homocysteine and higher serum folate levels compared to controls. Oxidative stress markers were not significantly different, suggesting no impaired oxidative balance in adult ADHD.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Adult ADHD (A-ADHD) is a complex neurodevelopmental disorder.
- Homocysteine and oxidative stress have been implicated in various psychiatric conditions.
Purpose of the Study:
- To investigate plasma homocysteine levels in adult ADHD.
- To evaluate oxidative stress parameters in adult ADHD patients.
Main Methods:
- Compared 32 adult ADHD patients with 32 controls.
- Measured plasma homocysteine, serum folate, vitamin B12, TAS, TOS, and OSI.
- Statistical analysis of biochemical markers between groups.
Main Results:
- Adult ADHD patients had significantly lower plasma homocysteine (p < .05).
- Adult ADHD patients exhibited significantly higher serum folate levels (p < .05).
- No significant differences were found in vitamin B12, TAS, TOS, or OSI (p > .05).
Conclusions:
- Oxidative balance does not appear to be impaired in adult ADHD.
- Homocysteine levels are lower in adult ADHD, contrasting with findings in other psychiatric disorders.
Objective:
In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD).
Method:
Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups.
Results:
Patients' plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups ( p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels ( p > .05).
Conclusion:
Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower.
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