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Updated: Apr 27, 2026

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
Venous thromboembolism is a product in proliferation of cancer cells
Le-Min Wang1, Qiang-Lin Duan1, Xiang-Hua Yi2
1Department of Cardiology, Tongji Hospital of Tongji University School of Medicine Shanghai 200065, China.
Abstract:
The pathogenesis of venous thromboembolism (VTE) in patients with cancer is related to the destruction of small veins and the intravenous formation of filamentous mesh-like structure by fibrinogen. The filamentous mesh-like filter can block hematogenous metastasis of cancer cells and also can stagnate blood cells, leading to venous thrombosis. Cancer cells have characteristics of malignancy and fast proliferation, and ischemic necrosis frequently occurs, and small veins were invaded and damaged. The formation of filamentous mesh-like structure has defense function and also may cause the occurrence of VTE. VTE is a product of the proliferation process of malignant cells.
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