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Updated: Apr 27, 2026
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Coagulation parameters in inflammatory bowel disease
Can Dolapcioglu1, Aliye Soylu2, Tulin Kendir3
1Department of Gastroenterology, Lutfi Kirdar Kartal Research and Training Hospital Kartal, Istanbul, Turkey.
Insights
Inflammatory bowel disease (IBD) patients show significant coagulation abnormalities, including elevated fibrinogen and factor VIII, increasing thromboembolic risk. These changes appear secondary to the disease process itself.
Area of Science:
- Hematology
- Gastroenterology
- Internal Medicine
Background:
- Thromboembolic events are a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD).
- These events can occur both within the gastrointestinal tract and at extraintestinal sites.
- Understanding coagulation alterations in IBD is crucial for risk assessment and management.
Purpose of the Study:
- To investigate alterations in coagulation parameters at different hemostasis steps in Crohn's disease and ulcerative colitis patients.
- To compare coagulation profiles of IBD patients with healthy individuals.
- To explore the relationship between coagulation abnormalities and disease activity in IBD.
Main Methods:
- Study included 51 IBD patients (Crohn's disease and ulcerative colitis) and 26 healthy controls.
- Measured plasma levels of prothrombin time (PT), activated partial thromboplastin time (APTT), antithrombin III (AT III), plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APC resistance (APCR).
- Factor V Leiden mutation was examined in all participants.
Main Results:
- IBD patients exhibited significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen, and thrombocytes compared to controls.
- Protein S, fibrinogen, plasminogen, and thrombocyte levels correlated with disease activity, varying by IBD type (Crohn's disease vs. ulcerative colitis).
- Two ulcerative colitis patients had a history of prior thromboembolic events.
Conclusions:
- Inflammatory bowel disease is associated with widespread coagulation abnormalities.
- These hemostatic alterations are likely secondary to the underlying disease process and multifactorial.
- Further research is needed to elucidate the precise mechanisms and clinical implications of these findings.
Abstract:
Thromboembolic events represent a major cause of morbidity and mortality in patients with inflammatory bowel disease and they may occur both at the gastrointestinal tract and at extraintestinal sites. This study aimed to examine the alterations in coagulation parameters involved at different steps of hemostasis in patients with Crohn's disease and ulcerative colitis, in comparison with healthy individuals. Fifty-one patients with inflammatory bowel disease and 26 healthy controls were included in this study. Plasma levels of PT, APTT, AT III, plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APCR were measured and factor V Leiden mutation was examined in both patients and controls. Two patients with ulcerative colitis had a history of previous thromboembolic event. Inflammatory bowel disease was associated with significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen and thrombocyte. Protein S, fibrinogen, plasminogen and thrombocyte levels were associated with disease activity, depending on the type of the disease (Crohn's disease or ulcerative colitis). The coagulation abnormalities detected in this study seems to be a secondary phenomena resulting from the disease process, which is more likely to be associated with a multitude of factors rather than a single abnormality.
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