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Related Concept Videos

Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

29
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Coagulation parameters in inflammatory bowel disease.

Can Dolapcioglu1, Aliye Soylu2, Tulin Kendir3

  • 1Department of Gastroenterology, Lutfi Kirdar Kartal Research and Training Hospital Kartal, Istanbul, Turkey.

International Journal of Clinical and Experimental Medicine
|July 5, 2014
PubMed
Summary

Inflammatory bowel disease (IBD) patients show significant coagulation abnormalities, including elevated fibrinogen and factor VIII, increasing thromboembolic risk. These changes appear secondary to the disease process itself.

Keywords:
Crohn’s diseaseInflammatory bowel disease (IBD)coagulationulcerative colitis

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Area of Science:

  • Hematology
  • Gastroenterology
  • Internal Medicine

Background:

  • Thromboembolic events are a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD).
  • These events can occur both within the gastrointestinal tract and at extraintestinal sites.
  • Understanding coagulation alterations in IBD is crucial for risk assessment and management.

Purpose of the Study:

  • To investigate alterations in coagulation parameters at different hemostasis steps in Crohn's disease and ulcerative colitis patients.
  • To compare coagulation profiles of IBD patients with healthy individuals.
  • To explore the relationship between coagulation abnormalities and disease activity in IBD.

Main Methods:

  • Study included 51 IBD patients (Crohn's disease and ulcerative colitis) and 26 healthy controls.
  • Measured plasma levels of prothrombin time (PT), activated partial thromboplastin time (APTT), antithrombin III (AT III), plasminogen, fibrinogen, D-dimer, factor V, factor VIII, protein C, protein S, and APC resistance (APCR).
  • Factor V Leiden mutation was examined in all participants.

Main Results:

  • IBD patients exhibited significantly higher levels of fibrinogen, PT, factor V, factor VIII, plasminogen, and thrombocytes compared to controls.
  • Protein S, fibrinogen, plasminogen, and thrombocyte levels correlated with disease activity, varying by IBD type (Crohn's disease vs. ulcerative colitis).
  • Two ulcerative colitis patients had a history of prior thromboembolic events.

Conclusions:

  • Inflammatory bowel disease is associated with widespread coagulation abnormalities.
  • These hemostatic alterations are likely secondary to the underlying disease process and multifactorial.
  • Further research is needed to elucidate the precise mechanisms and clinical implications of these findings.