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NSAIDs and bleeding in periodontal surgery.

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Pre-operative ibuprofen and diclofenac sodium significantly increase bleeding time and blood loss during periodontal surgery. This suggests caution when using these NSAIDs before such procedures.

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Area of Science:

  • Periodontal Surgery
  • Pharmacology
  • Clinical Research

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain management.
  • The effect of NSAIDs on bleeding during periodontal surgery requires careful evaluation.

Purpose of the Study:

  • To compare the clinical effects of ibuprofen and diclofenac sodium on bleeding during periodontal surgery.
  • To assess the impact of pre-operative NSAID administration on bleeding parameters.

Main Methods:

  • A study involving 13 healthy participants undergoing periodontal surgery.
  • Participants were divided into three groups: control, ibuprofen (T1), and diclofenac sodium (T2).
  • Bleeding times and peri-operative blood loss were recorded.

Main Results:

  • Both ibuprofen and diclofenac sodium groups showed statistically significant increases in bleeding time and peri-operative blood loss compared to the control group.
  • Mean bleeding time was higher in the ibuprofen group (2.55 min) and diclofenac sodium group (1.84 min) versus control (1.24 min).
  • Mean blood loss was significantly greater in the ibuprofen (62.03 ml) and diclofenac sodium (51.08 ml) groups compared to control (37.50 ml).

Conclusions:

  • Pre-operative administration of ibuprofen and diclofenac sodium can increase bleeding time.
  • These NSAIDs may lead to increased peri-operative blood loss in periodontal surgery.
  • Findings suggest a need for caution when using these medications before surgical procedures.