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Er:Yb:NaY2F5O up-converting nanoparticles for sub-tissue fluorescence lifetime thermal sensing
Ol A Savchuk1, P Haro-González, J J Carvajal
1Física i Cristal.lografia de Materials i Nanomaterials (FiCMA-FiCNA)- EMaS, Universitat Rovira i Virgili (URV), Campus Sescelades, C/ Marcel.li Domingo s/n, E-43007, Tarragona, Spain. joanjosep.carvajal@urv.cat.
Nanoscale
|July 5, 2014
Summary
Er:Yb:NaY2F5O up-conversion nanoparticles show enhanced thermal sensitivity for non-contact biomedical thermometry. This study provides the first evidence of sub-tissue lifetime fluorescence thermal sensing using these advanced nanomaterials.
Area of Science:
- Nanomaterials Science
- Biomedical Engineering
- Optical Physics
Background:
- Non-contact thermometry is crucial for high-resolution thermal sensing and imaging in biomedical applications.
- Up-conversion nanoparticles (UCNPs) offer unique optical properties for advanced sensing modalities.
Purpose of the Study:
- To investigate the potential of Er:Yb:NaYF4 and Er:Yb:NaY2F5O UCNPs as thermal sensors.
- To evaluate the performance of Er:Yb:NaY2F5O UCNPs for sub-tissue thermal sensing applications.
Main Methods:
- Lifetime-based luminescent thermometry was employed to assess thermal sensing capabilities.
- Comparative analysis of thermal sensitivity between Er:Yb:NaYF4 and Er:Yb:NaY2F5O nanocrystals.
- Ex vivo experiments were conducted to demonstrate sub-tissue thermal sensing.
Main Results:
- Er:Yb:NaY2F5O nanocrystals exhibited higher thermal sensitivity compared to Er:Yb:NaYF4.
- The lifetime thermal coefficient of Er:Yb:NaY2F5O is comparable to existing nano-sized luminescent thermal sensors.
- Successful demonstration of sub-tissue lifetime fluorescence thermal sensing using Er:Yb:NaY2F5O UCNPs.
Conclusions:
- Er:Yb:NaY2F5O UCNPs are promising candidates for advanced non-contact biomedical thermometry.
- These UCNPs enable high-resolution thermal sensing within biological tissues.
- The findings pave the way for novel diagnostic and monitoring tools in medicine.
