Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

Diphtheria

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...

Encephalitis l: Introduction

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

Cross-reactivity

Cross-reactivity

Encephalitis ll: Pathophysiology

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Elimination of human rabies in Goa, India through an integrated One Health approach.

Nature communications·2022

Same author

Epidemiology and control of raccoon rabies: an update.

Revue scientifique et technique (International Office of Epizootics)·2020

Same author

[Epidémiologie et prophylaxie de la rage du raton laveur : problèmes actuels].

Revue scientifique et technique (International Office of Epizootics)·2020

Same author

The transport of liquids in softwood: timber as a model porous medium.

Scientific reports·2020

Same author

Historical, current and expected future occurrence of rabies in enzootic regions.

Revue scientifique et technique (International Office of Epizootics)·2019

Same author

Global rabies management: perspectives on regional strategies for prevention and control.

Revue scientifique et technique (International Office of Epizootics)·2019

Same journal

Serological and Molecular Surveillance of Influenza A Virus in Dogs and Cats in Central Chile.

Zoonoses and public health·2026

Same journal

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids.

Zoonoses and public health·2026

Same journal

Mapping High-Rate Clusters of Animal Contact-Related Human Salmonella enterica Single-State Outbreaks in the United States, 2009-2022: A Spatial Epidemiological Approach to Inform Public Health Surveillance.

Zoonoses and public health·2026

Same journal

Barriers to Canine Rabies Vaccination in Nigeria: Implications for Rabies Elimination by 2030.

Zoonoses and public health·2026

Same journal

Determining the Environmental and Ecological Factors Associated With Poultry Farm Spillover of Highly Pathogenic Avian Influenza (H5N1) in British Columbia, Canada.

Zoonoses and public health·2026

Same journal

Epidemiological Patterns of Leishmaniasis in Two Northeastern Algerian Wilayas: A Comparative Study of Environmental and Climatic Factors.

Zoonoses and public health·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

Recurrent temporary paralysis reported after human rabies post-exposure prophylaxis.

V M Dato¹, E R Campagnolo, D U Shah

¹Pennsylvania Department of Health, Bureau of Epidemiology, Harrisburg, PA, USA.

Zoonoses and Public Health

|July 5, 2014

Summary

This summary is machine-generated.

Rabies post-exposure prophylaxis (PEP) can cause adverse events. This case study details recurrent temporary paralysis following rabies PEP, highlighting diagnostic challenges.

Keywords:

Post-exposure prophylaxis bat bat-variant rabies human diploid cell vaccine human rabies immunoglobulin purified chick embryo cell vaccine rabies rabies exposure rabies immunization recurrent temporary paralysis

More Related Videos

Postmortem Diagnosis of Rabies in Animals by the Updated, Multiplexed LN34 Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Postmortem Diagnosis of Rabies in Animals by the Updated, Multiplexed LN34 Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Published on: May 2, 2025

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

Related Experiment Videos

Last Updated: Apr 27, 2026

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

Postmortem Diagnosis of Rabies in Animals by the Updated, Multiplexed LN34 Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Postmortem Diagnosis of Rabies in Animals by the Updated, Multiplexed LN34 Real-Time Reverse Transcription-Polymerase Chain Reaction Assay

Published on: May 2, 2025

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

Area of Science:

Neurology
Immunology
Infectious Diseases

Background:

Adverse events following rabies post-exposure prophylaxis (PEP) are known but causality can be challenging to establish.
Rabies PEP is crucial for preventing rabies virus infection after potential exposure.

Observation:

A patient developed recurrent temporary paralysis immediately after initiating rabies PEP post-bat exposure.
Paralysis episodes recurred after the initial dose and on day 3 of the PEP regimen.

Findings:

The patient experienced multiple distinct episodes of temporary paralysis lasting over two years.
Rabies PEP was discontinued before a serologic response was achieved.

Implications:

This case highlights a potential, albeit rare, adverse neurological event associated with rabies PEP.
Further investigation is needed to understand the mechanism and frequency of such paralysis in relation to rabies vaccination.