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Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation

Albert J Keung1, Caleb J Bashor1, Szilvia Kiriakov2

  • 1Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Cell
|July 5, 2014
PubMed
Summary

Researchers engineered chromatin regulators (CRs) to understand gene transcription control. This synthetic biology approach revealed complex regulatory logic, offering design principles for cellular engineering.

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