Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The evolution of hematopoietic models through a clonal lens.

Blood·2026

Same author

Social status impacts T-cell responses through synapse strength in the prefrontal cortex.

Cell research·2026

Same author

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC.

Nature cancer·2026

Same author

Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneity.

Molecular systems biology·2026

Same author

Interleukin 4 selectively expands functional type 1 conventional dendritic cells from bone marrow progenitors.

Cell reports·2025

Same author

Guidelines for T cell nomenclature.

Nature reviews. Immunology·2025

Same journal

Multidisciplinary Characterization of Rare MPL Y591 and R592 Variants in Myeloid Disorders: From Clinical Correlation and Literature-Based Evidence to In Silico Predictors and Structural Bioinformatics.

Experimental hematology·2026

Same journal

Integrin alpha 4 inhibition prolongs the survival of NSG mice engrafted with CD19-negative post-CART19 relapsed B-ALL.

Experimental hematology·2026

Same journal

RNA Binding Protein PCBP1 Functions in the Endothelial-to-Hematopoietic Transition During Hematopoietic Stem Cell Formation.

Experimental hematology·2026

Same journal

Image-enabled cell sorting permits prospective isolation of primitive hematopoietic stem cell subsets with distinct functional potential.

Experimental hematology·2026

Same journal

Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.

Experimental hematology·2026

Same journal

Adaptive Immune Remodeling in Sickle Cell Disease: Linking Hemolysis-Driven Inflammation to Immune Dysfunction.

Experimental hematology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Published on: April 14, 2015

Cellular barcoding: a technical appraisal.

Shalin H Naik¹, Ton N Schumacher², Leïla Perié³

¹Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

Experimental Hematology

|July 5, 2014

Summary

This summary is machine-generated.

Cellular barcoding uses genetic tags to track individual cell fates, offering powerful insights into biological processes like hematopoiesis. This review discusses its challenges, strengths, and future potential in cell biology research.

More Related Videos

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Related Experiment Videos

Last Updated: Apr 27, 2026

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Genetic Barcoding with Fluorescent Proteins for Multiplexed Applications

Published on: April 14, 2015

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Area of Science:

* Molecular Biology
* Genetics
* Cell Biology

Background:

* Cellular barcoding is a rapidly advancing technology for tracking individual cell lineages.
* It utilizes unique, heritable genetic identifiers (barcodes) to tag cells.
* Despite its power, the technology faces significant technical and analytical hurdles.

Purpose of the Study:

* To review the challenges associated with cellular barcoding.
* To highlight the capabilities and limitations of this technology.
* To illustrate its application in understanding hematopoiesis and its future prospects.

Main Methods:

* Literature review of cellular barcoding techniques and applications.
* Analysis of technical and analytical challenges in the field.
* Case study illustrating the use of cellular barcoding in hematopoiesis research.

Main Results:

* Identified key technical challenges including barcode complexity and data analysis.
* Demonstrated the power of cellular barcoding in tracing cell fates.
* Highlighted limitations such as potential barcode loss or off-target effects.

Conclusions:

* Cellular barcoding is a transformative tool with substantial potential in biological research.
* Addressing current challenges is crucial for maximizing its utility.
* Future applications in developmental biology and disease modeling are promising.