Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dosimetric evaluation of beam block techniques in helical tomotherapy for extranodal nasal-type NK/T-cell lymphoma.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026
Same author

In-Situ Metabolic Profiling of Single Living Cells by Liquid Secondary Ion Mass Spectrometry.

Analytical chemistry·2026
Same author

Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8<sup>+</sup> T Cell Exhaustion and Ocular MALT Lymphoma Progression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Analysis of factors influencing changes in patient-reported quality of life among patients with bladder cancer.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same author

Affinity Proteomics-Based Non-Invasive Detection of Clinically Significant Liver Disease.

Alimentary pharmacology & therapeutics·2026
Same author

Megavoltage CT enhancement for cervical cancer tomotherapy using a generative adversarial network with deformable convolution and self-attention.

Medical physics·2026
Same journal

Recent developments of textile-based triboelectric nanogenerators for smart sports applications.

Biosensors & bioelectronics·2026
Same journal

One-Tube RPA-CRISPR-Cas13a assay with rational design for single-molecule detection of waterborne viruses in drinking water treatment.

Biosensors & bioelectronics·2026
Same journal

AI-driven photophysics-aware design of fluorescent probes with applications in α-synuclein biosensing and inhibitor screening.

Biosensors & bioelectronics·2026
Same journal

Three-dimensional helical integration of high-density linear microelectrode arrays and their cross-tissue applications.

Biosensors & bioelectronics·2026
Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026
Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

16.2K

Reversible detection of vancomycin using peptide-functionalized cantilever array sensor.

Xiaojing Bai1, Baoping Lu1, Xuejuan Chen1

  • 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Biosensors & Bioelectronics
|July 6, 2014
PubMed
Summary
This summary is machine-generated.

A novel peptide-functionalized cantilever sensor enables reversible vancomycin detection. This sensitive biosensor shows potential for real-world applications in biological fluid analysis.

Keywords:
Cantilever array sensorPeptideReversibilitySerumVancomycin

More Related Videos

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

4.8K
The Use of a &#946;-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

7.7K

Related Experiment Videos

Last Updated: Apr 27, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

16.2K
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

4.8K
The Use of a &#946;-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

7.7K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Vancomycin is a critical antibiotic for treating serious bacterial infections.
  • Accurate and rapid detection of vancomycin is essential for therapeutic drug monitoring.
  • Existing detection methods may lack specificity or reversibility.

Purpose of the Study:

  • To develop a reversible detection method for vancomycin using a peptide-functionalized cantilever array sensor.
  • To investigate the role of a peptide linker in sensor performance.
  • To assess the sensor's specificity and applicability in biological samples.

Main Methods:

  • Functionalization of a cantilever array sensor with a designed peptide (Cys-Gly-Gly-Gly-Gly-L-Lys-D-Ala-D-Ala).
  • Utilizing differential deflection between sensing (peptide-modified) and reference (MCH-modified) cantilevers.
  • Quantifying vancomycin concentration based on surface stress changes.

Main Results:

  • The peptide linker was crucial for sensor response.
  • A linear relationship was observed between reciprocal deflection and reciprocal vancomycin concentration (2-100 μM, R=0.993).
  • Achieved a detection limit of 0.2 μM (S/N=3) with high specificity against other antibiotics.
  • Demonstrated reversible detection and successful application in serum samples.

Conclusions:

  • The developed cantilever array sensor offers a sensitive and reversible method for vancomycin detection.
  • The sensor's design, incorporating a specific peptide linker, enhances performance.
  • This technology holds promise for clinical diagnostics and therapeutic drug monitoring in biological fluids.