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Relation of mean platelet volume with obstructive adenoid hypertrophy in children
Serap Onder1, Basak Caypinar1, Asli Sahin-Yilmaz1
1Umraniye Research and Education Hospital, Department of Otolaryngology, Istanbul, Turkey.
Insights
Mean platelet volume (MPV) does not appear to be a reliable indicator for obstruction caused by adenoid hypertrophy in children. This study found no significant relation between MPV levels and the severity of airway obstruction.
Area of Science:
- Pediatric Otolaryngology
- Hematology
- Respiratory Medicine
Background:
- Adenoid hypertrophy (AH) is a frequent cause of chronic upper airway obstruction in children.
- Upper airway obstruction can lead to chronic alveolar hypoventilation and pulmonary vasoconstriction.
- Mean platelet volume (MPV), a marker of platelet activation, has been implicated in cardiovascular disease pathophysiology.
Purpose of the Study:
- To investigate if mean platelet volume (MPV) can serve as an indicator of obstruction severity in children with adenoid hypertrophy (AH).
Main Methods:
- A cohort of 61 children undergoing adenoidectomy was studied.
- Blood parameters including MPV, white blood cell count, and platelet count were measured preoperatively and 3 months postoperatively.
- Standardized questionnaires assessed upper airway obstruction (UAO) symptoms before and after surgery.
Main Results:
- No significant differences were observed in preoperative versus postoperative MPV or platelet count.
- White blood cell counts were significantly higher preoperatively.
- Preoperative UAO symptom scores were significantly higher than postoperative scores, indicating symptom improvement post-adenoidectomy.
Conclusions:
- Mean platelet volume (MPV) does not show a significant relationship with obstructive adenoid hypertrophy.
- MPV cannot be reliably used as a biomarker for assessing obstruction due to adenoid hypertrophy.
Objective:
Adenoid hypertrophy (AH) is a common etiology of chronic upper airway obstruction. Upper respiratory tract obstruction may cause chronic alveolar hypoventilation and pulmonary vasoconstriction. In one previous study in patients with obstructive sleep apnea (OSA), it has been claimed that mean platelet volume (MPV), an indicator of platelet activation is increased and that MPV has an important role in the pathophysiology of cardiovascular diseases. We investigated in our study if MPV can be used as an indicator of obstruction due to adenoid hypertrophy.
Methods:
Our study includes 61 children that underwent adenoidectomy with a mean age of 7.12 (± 2.373). White blood cell, platelet count, MPV, platelet crit and platelet distribution width levels were measured before and 3 months after adenoidectomy. Children's symptoms for upper airway obstruction (UAO) (presence of snoring, mouth breathing or difficulty in breathing during sleep, obstructive breathing or apnea during sleep) were questioned in the preoperative and postoperative period by a standardized questionnaire.
Results:
There was no significant difference between preoperative and postoperative mean values of MPV, hemoglobin, platelet count (p > 0.05). White blood cell levels were significantly higher in the preoperative period values compared with postoperative period values (p < 0.05). Preoperative UAO scores were significantly higher than the postoperative UAO scores. After stratification of the degree of obstruction (as mild, moderate and severe) there was no significant difference in between groups in terms of MPV values.
Conclusion:
There was no significant relation between MPV levels and obstructive adenoid hypertrophy.
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