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2-Chlorobenzylidene malonitrile (CS) causes spindle disturbances in V79 Chinese hamster cells
E Schmid1, M Bauchinger, K Ziegler-Skylakakis
1Institut für Strahlenbiologie, Gesellschaft für Strahlen- und Umweltforschung, Neuherberg/Munich, F.R.G.
Mutation Research
|June 1, 1989
Abstract:
Exposure of V79 Chinese hamster cells to 2-chlorobenzylidene malonitrile (CS), a chemical used as a sensory irritant for riot control, caused a concentration-dependent increase in the incidence of spindle disturbances. A C-mitotic effect with the appearance of C-metaphases, a metaphase block and the concomitant disappearance of ana-telophase figures were observed after a 3-h treatment. The results indicate that CS might induce aneuploidy in mammalian cells by interacting with the mitotic apparatus.