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Synthesis and in silico studies of pyrrolidine sulfonamide based dipeptides as β-gluscosidase inhibitors
B Santosh Kumar1, A Raghavendra Guru Prasad2, G Madhu3
1Department of Chemistry, Sri Krishnadevaraya University, Etukalapally Anantapur, A.P. 515005, India.
Abstract:
A series of novel pyrrolidine sulfonamide derivatives were designed, synthesized and screened in silico for their β-gluscosidase inhibitory activity. The results showed that the pyrrolidine derivatives exhibited moderate inhibitory activity against human β-gluscosidases inhibitors. The structure-activity relationships were also briefly discussed. The studies indicated that compounds of Series B with imidazole sulfonyl group were the most potent inhibitors compared to the other compounds under investigation.
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