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Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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Related Experiment Video

Updated: Apr 27, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Easy-to-use comprehensive speckle-tracking approach for cardiac resynchronization therapy.

Yasuhide Mochizuki1, Hidekazu Tanaka, Kazuhiro Tatsumi

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 8, 2014
PubMed
Summary

Assessing left ventricular (LV) dyssynchrony and global circumferential strain (GCS) together predicts cardiovascular events in cardiac resynchronization therapy (CRT) patients. This combined, quick analysis using speckle-tracking strain has clinical implications for CRT.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Left ventricular (LV) dyssynchrony is a key factor in cardiac resynchronization therapy (CRT) response.
  • LV myocardial viability also influences CRT outcomes.
  • A simple, combined assessment method is needed.

Purpose of the Study:

  • To evaluate the combined prognostic value of LV dyssynchrony and global circumferential strain (GCS) in patients undergoing CRT.
  • To determine if LV dyssynchrony and GCS independently predict cardiovascular events.
  • To assess the efficiency of a combined speckle-tracking strain analysis.

Main Methods:

  • Studied 132 patients undergoing CRT.
  • Assessed LV dyssynchrony using anteroseptal-to-posterior wall delay (≥130 ms) via 2D speckle-tracking radial strain.
  • Determined global circumferential strain (GCS) from the same mid-LV short-axis view.

Main Results:

  • Patients with GCS >3.9% had fewer cardiovascular events (log-rank P=0.034).
  • Both LV dyssynchrony and GCS were independently associated with cardiovascular events (multivariate Cox analysis).
  • Analysis of both parameters from the same view took only 2±1 min per patient.

Conclusions:

  • Combined assessment of LV dyssynchrony and GCS using speckle-tracking strain is efficient and prognostic.
  • This easy-to-use method from a single view may have significant clinical implications for CRT patient selection and management.