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Published on: January 25, 2017
[Immune function of interleukin-33 and its relation to human diseases]
1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Abstract:
Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family expressed in a wide range of organs and cells. IL-33 is a dual-functional molecule: as a classical cytokine it induces immune response and it also regulates gene transcription in the nucleus. Altered expression of IL-33 has been observed in various human diseases such as inflammation, autoimmune diseases, and virus infection. The article reviews advances on immune function of IL-33 and its relation to a variety of human diseases.
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