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Polyoma small T antigen triggers cell death via mitotic catastrophe

A T Pores Fernando1, S Andrabi2, O Cizmecioglu1

  • 11] Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Oncogene
|July 8, 2014
PubMed
Summary

Polyoma small T antigen (PyST) causes mitotic arrest and cell death by inhibiting protein phosphatase 2A (PP2A). This mechanism offers a potential strategy for targeting cancer cells with p53 mutations.

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