Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.2K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

2.0K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.0K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

643
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
643
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

493
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
493
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.9K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.9K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

491
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
491

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Cardiogenomics in Athletes.

International journal of molecular sciences·2026
Same author

Perceptions, Attitudes, and Experiences of Statin Therapy Among Master Athletes.

The American journal of cardiology·2026
Same author

Progression of Ascending Aortic Dimensions in Masters Endurance Athletes.

JACC. Advances·2025
Same author

Comprehensive Prevention of Exercise-Related Sudden Cardiac Arrest or Death.

The Canadian journal of cardiology·2024
Same author

New Insights and Recommendations for Athletes With Hypertrophic Cardiomyopathy.

The Canadian journal of cardiology·2024
Same author

Masters athlete screening study (MASS): incidence of cardiovascular disease and major adverse cardiac events and efficacy of screening over five years.

European journal of preventive cardiology·2023

Related Experiment Video

Updated: Apr 27, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

6.8K

Macrotroponin causing elevation in cardiac troponin I.

Sophia L Wong1, Saul Isserow1, Morris Pudek1

  • 1Vancouver General Hospital/University of British Columbia, Vancouver, British Columbia, Canada.

The Canadian Journal of Cardiology
|July 8, 2014
PubMed
Summary

Macro-troponin, a troponin-immunoglobulin complex, can cause persistently high cardiac troponin I (cTnI) levels. This diagnostic challenge requires careful consideration in patients with atypical chest pain.

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

16.1K
Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

5.9K

Related Experiment Videos

Last Updated: Apr 27, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

6.8K
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

16.1K
Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

5.9K

Area of Science:

  • Clinical Chemistry
  • Cardiology
  • Immunology

Background:

  • Cardiac troponin I (cTnI) is a critical biomarker for diagnosing acute coronary syndrome.
  • Elevated cTnI levels typically indicate myocardial injury.
  • Interference in troponin assays can lead to misdiagnosis.

Observation:

  • A 57-year-old male presented with recurrent atypical chest pain and persistently elevated cTnI levels.
  • Standard diagnostic criteria for acute coronary syndrome, including troponin rise and fall, were not met.
  • Investigation revealed the presence of macrotroponin, a troponin-immunoglobulin complex.

Findings:

  • Macrotroponin can cause falsely elevated cTnI measurements.
  • The cTnI levels were inconsistent with the patient's clinical presentation.
  • The characteristic rise and/or fall pattern of cTnI in acute myocardial infarction was absent.

Implications:

  • Macrotroponin should be considered in cases of unexplained elevated cTnI.
  • Accurate diagnosis requires differentiating macrotroponin from true myocardial injury.
  • Effective communication between clinical and laboratory teams is crucial for managing macrotroponin.
  • This condition highlights the importance of understanding immunoassay interferences in clinical diagnostics.