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Feedback Inhibition00:46

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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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Related Experiment Video

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Authors' reply

Guangwei Li1, Ping Zhang2, Edward W Gregg2

  • 1Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China; Center of Endocrinology and Cardiovascular Disease, National Center of Cardiology and Fuwai Hospital, Beijing, China.

The Lancet. Diabetes & Endocrinology
|July 8, 2014
PubMed
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No abstract available in PubMed .

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