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[Heart-lung transplantation].

K S Kristensen, S A Mortensen, A Høegholm

    Ugeskrift for Laeger
    |May 29, 1989
    PubMed
    Summary

    Heart-lung transplantation (HLT) is a viable treatment for severe lung diseases, with a two-year survival rate around 60%. This summary covers the procedure, costs, and the first Danish HLT cases.

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    Area of Science:

    • Cardiothoracic Surgery
    • Transplantation Medicine
    • Pulmonology

    Background:

    • Heart-lung transplantation (HLT) is an established procedure for end-stage cardiopulmonary diseases.
    • Primary indications include pulmonary hypertension and Eisenmenger's syndrome, with expanding use in parenchymal lung diseases.

    Observation:

    • Over 200 HLTs have been performed globally, with recent reviews indicating approximately 60% two-year survival.
    • The direct cost is around £17,000, excluding lifelong immunosuppression, follow-up, and donor waiting costs.
    • Denmark estimates an annual need for ten HLTs, initially managed via European centers.

    Findings:

    • Presents case reports of the first two Danish patients successfully undergoing HLT in England for emphysema.
    • HLT involves replacing the thoracic organs, with potential for recipient heart donation.

    Implications:

    • Successful HLT in Danish patients highlights the procedure's potential.
    • Future self-sufficiency in Denmark necessitates utilizing local donors, requiring revised criteria for determining death.

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