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Related Experiment Videos

Study on pathogenesis of Enterococcus faecalis in urinary tract.

T Hirose1, Y Kumamoto, N Tanaka

  • 1Department of Urology, Sapporo Medical College, Japan.

Urological Research
|January 1, 1989
PubMed
Summary

Enterococcus faecalis increasingly causes complicated urinary tract infections. This study shows E. faecalis can be directly pathogenic in sufficient numbers or indirectly pathogenic when co-infecting with bacteria like E. coli.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Urology

Background:

  • Enterococcus faecalis is an emerging cause of complicated urinary tract infections (cUTIs).
  • The specific mechanisms underlying E. faecalis pathogenicity in the urinary tract remain incompletely understood.

Purpose of the Study:

  • To elucidate the pathogenic mechanisms of Enterococcus faecalis in experimental urinary tract infections.
  • To determine if E. faecalis possesses intrinsic virulence factors or relies on co-infection for pathogenicity.

Main Methods:

  • Induction of experimental urinary tract infections in a murine model.
  • Isolation and quantification of E. faecalis from infected bladders and kidneys.
  • Co-infection models with common uropathogens like Escherichia coli.

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Main Results:

  • E. faecalis demonstrated direct pathogenicity when present in high bacterial loads.
  • E. faecalis exhibited indirect pathogenicity when co-infecting with other typical urinary tract bacteria, such as E. coli.
  • The study confirmed E. faecalis as a significant pathogen in complicated UTIs.

Conclusions:

  • Sufficient bacterial numbers enable direct E. faecalis pathogenicity in the urinary tract.
  • E. faecalis can contribute to UTI pathogenesis through synergistic interactions with other uropathogens.
  • Understanding these mechanisms is crucial for managing complicated urinary tract infections.