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Updated: Apr 27, 2026

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
Implementation of a human milk management center
Diane L Spatz1, Katherine J Schmidt, Sue Kinzler
1University of Pennsylvania, Philadelphia, and the Lactation Program, Children's Hospital of Philadelphia, Pennsylvania (Dr Spatz); University of Pennsylvania, Philadelphia (Ms Schmidt), and Director of Patient and Family Services-Nutrition Services, Children's Hospital of Philadelphia, Pennsylvania (Ms Kinzler).
Abstract:
Current hospital practices surrounding the use of human milk and fortification are suboptimal. Safety of milk preparation should be a priority, as should optimization of the milk to meet the nutritional needs of hospitalized infants. This article describes the implementation of a human milk management center (HMMC) at a children's hospital. This centralized center allows for milk to be safely prepared under aseptic technique. In addition, the HMMC staff can analyze milk composition. The widely variable nutrient composition of human milk has been well established and, therefore, should be considered when fortifying human milk. The HMMC staff have the ability to perform creamatocrits on milk, conduct human milk nutrient analysis, and make skim milk for infants. The processes for developing an HMMC are also detailed in this article.

