Related Experiment Video

Updated: Apr 27, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

27.4K

A registry on distal popliteal and infrapopliteal revascularization with coronary drug-eluting stents

Arturo Giordano1, Stefano Messina, Michele Polimeno

  • 1aUnità Operativa di Interventistica Cardiovascolare, Presidio Ospedaliero Pineta Grande, Castelvolturno bUnità Operativa di Emodinamica, Casa di Salute Santa Lucia, San Giuseppe Vesuviano cDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 8, 2014
PubMed

Insights

Coronary drug-eluting stents (DESs) show promise for treating critical limb ischemia (CLI) in the popliteal and infrapopliteal arteries. This study found DES implantation feasible, safe, and effective in selected patients with focal lesions.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Endovascular Therapy

Background:

  • Critical limb ischemia (CLI) due to popliteal and infrapopliteal artery disease presents significant challenges for endovascular treatment.
  • Coronary balloon-expandable drug-eluting stents (DESs) have shown potential, but their risk-benefit profile in real-world CLI patients requires further evaluation.

Purpose of the Study:

  • To assess the feasibility, safety, and effectiveness of coronary DES implantation for treating focal lesions in the distal popliteal and infrapopliteal arteries in patients with CLI.
  • To evaluate the outcomes of DES use in this challenging patient population.

Main Methods:

  • Retrospective analysis of institutional databases to identify patients undergoing DES implantation for distal popliteal or infrapopliteal artery disease.
  • Systematic collection of baseline, lesion, procedural, and outcome data.

Main Results:

  • Twenty-five patients with CLI were treated with coronary DES (sirolimus-eluting stents were most common).
  • Significant improvement in Fontaine stage was observed at 1 month (92.0%) and long-term (88.0%).
  • No repeat revascularizations or amputations occurred; two patients died late after the procedure.

Conclusions:

  • Coronary balloon-expandable DES implantation is a feasible, safe, and effective option for selected patients with focal lesions in the distal popliteal and infrapopliteal arteries.
  • This approach offers a promising solution for managing CLI in these challenging arterial segments.
Abstract

More Related Videos

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

2.3K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

2.8K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
653
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
442
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
627
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
758
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
522