Related Experiment Video
Updated: Apr 27, 2026
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Mean platelet volume is associated with myocardial perfusion defect in diabetic patients
Savas Sarikaya1, Safak Sahin2, Lutfi Akyol3
1Department of Cardiology, School of Medicine, Bozok University, Yozgat, Turkey.
Insights
Higher mean platelet volume (MPV) is linked to myocardial perfusion defects in diabetic patients. This finding suggests MPV may serve as an independent indicator of myocardial ischemia in this population.
Area of Science:
- Cardiology
- Diabetology
- Hematology
Background:
- Diabetes mellitus is associated with an increased risk of cardiovascular disease.
- Myocardial perfusion defects are a significant indicator of coronary artery disease.
- Platelet indices, including mean platelet volume (MPV), are emerging markers in cardiovascular risk assessment.
Purpose of the Study:
- To investigate the association between mean platelet volume (MPV) and myocardial perfusion defects in diabetic patients.
- To determine if MPV is an independent predictor of myocardial ischemia in individuals with diabetes.
Main Methods:
- Retrospective analysis of 44 diabetic patients with myocardial perfusion defects and 44 matched diabetic patients without defects.
- Assessment of mean platelet volume (MPV) levels in both groups.
- Multivariate logistic regression analysis to identify independent predictors of myocardial perfusion defects.
Main Results:
- Mean platelet volume (MPV) was significantly higher in diabetic patients with myocardial perfusion defects compared to those without (8.76 ± 0.76 fl vs. 8.25 ± 0.78 fl, p = 0.003).
- No significant differences were observed in glucose, lipid profiles, HbA1c, or BMI between the groups.
- Multivariate analysis identified MPV as the sole independent variable associated with myocardial perfusion defects (OR: 2.401, 95% CI: 1.298-4.440, p = 0.013).
Conclusions:
- Elevated mean platelet volume (MPV) is associated with myocardial perfusion defects in diabetic patients.
- Higher MPV is an independent predictor of myocardial perfusion defects in this population.
- MPV may serve as a valuable biomarker for identifying myocardial ischemia in diabetic individuals.
Aim:
Our aim was to evaluate whether there was a relationship between mean platelet volume and myocardial perfusion defect in diabetic patients using myocardial perfusion imaging.
Methods:
Forty-four diabetic patients with myocardial perfusion defect (group 1) and 44 diabetic patients without myocardial perfusion defect (group 2), matched for age and gender, were retrospectively examined. Levels of mean platelet volume (MPV) in the two groups were assessed.
Results:
MPV was higher in group 1 than group 2 patients (8.76 ± 0.76 and 8.25 ± 0.78 fl), respectively, p = 0.003). Levels of glucose, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, haemoglobin (Hb) and glycosylated haemoglobin (HbA1c), and body mass index (BMI) in the two groups were not statistically significantly different. Multivariate logistic regression analyses showed that MPV was the only variable independently associated with myocardial perfusion defects (OR: 2.401, 95% CI: 1.298-4.440, p = 0.013).
Conclusion:
This study showed that higher MPV was associated with myocardial perfusion defects. Higher MPV in diabetic patients was independently related to myocardial perfusion defects and may be an indicator of myocardial ischaemia.
More Related Videos
08:13In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018