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Immune function of peripheral T cells in patients with venous thromboembolism or coronary artery atherosclerosis

Lin Zhou1, Haoming Song1, Wenjun Xu1

  • 1Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|July 9, 2014
PubMed

Insights

Patients with venous thromboembolism (VTE) and coronary artery atherosclerosis (CAA) show reduced T cell function and elevated hs-CRP. These findings suggest immune and inflammatory mechanisms contribute to both arterial and venous thrombosis.

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Arterial thrombotic diseases share risk factors with venous thromboembolism (VTE).
  • T lymphocyte subsets (CD3, CD4, CD8) and CD4/CD8 ratio are crucial immune markers.
  • High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation.

Purpose of the Study:

  • To compare T lymphocyte expression (CD3, CD4, CD8), CD4/CD8 ratio, and hs-CRP levels in VTE patients, coronary artery atherosclerosis (CAA) patients, and healthy controls.
  • To elucidate the role of immune and inflammatory factors in VTE and CAA.

Main Methods:

  • Recruited 51 VTE patients, 114 CAA patients, and 82 healthy subjects.
  • Measured T lymphocyte expression (CD3, CD4, CD8) and CD4/CD8 ratio.
  • Quantified serum hs-CRP levels.

Main Results:

  • VTE patients exhibited significantly reduced CD3 and CD8 expression and an increased CD4/CD8 ratio compared to healthy subjects.
  • VTE and CAA patients showed comparable T lymphocyte profiles and higher hs-CRP levels than healthy controls.
  • A higher proportion of VTE or CAA patients had reduced CD3+/CD8+ T cells or elevated CD4/CD8 ratios versus healthy subjects.

Conclusions:

  • Patients with VTE or CAA have impaired T cell antigen recognition, signal transduction, and cytotoxic function.
  • Inflammatory and immune mechanisms are implicated in the pathogenesis of both venous and arterial thrombosis.
Abstract

Keywords:
Aterosclerose coronáriaCoronary atherosclerosisCélula TFunção imunológicaImmune functionT cellTromboembolismo venosoVenous thromboembolism

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