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Does cardiovascular protection translate into renal protection?
Gema Ruiz-Hurtado1, Luis M Ruilope1
1Hypertension Unit, Instituto de Investigación imas 12, Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, 28041 Madrid, Spain.
Nature Reviews. Cardiology
|July 9, 2014
Summary
Cardiovascular and kidney diseases share origins and risk factors. Simultaneous protection against both can be achieved with the same therapies, suggesting new treatment avenues for patients with co-existing conditions.
Area of Science:
- Nephrology and Cardiology
- Chronic Disease Pathophysiology
Background:
- Cardiovascular disease (CVD) and chronic kidney disease (CKD) frequently coexist due to shared risk factors and origins.
- CKD progression involves additional risk factors that exacerbate both conditions, complicating research and treatment.
Approach:
- Examined existing clinical trial data, particularly from arterial hypertension studies.
- Focused on identifying therapeutic strategies that offer concurrent cardiovascular and renal protection.
Key Points:
- Previous CKD progression studies, often in diabetic nephropathy, used smaller cohorts insufficient for cardiovascular outcome analysis.
- Arterial hypertension trials suggest unified therapeutic approaches can benefit both cardiovascular and renal health simultaneously.
- Simultaneous cardiovascular and renal protection has not been clearly demonstrated in prior CKD progression studies.
Conclusions:
- Investigating factors driving rapid progression in both cardiovascular disease and CKD is crucial.
- Developing novel therapies targeting shared pathways could significantly improve outcomes for patients with comorbid CVD and CKD.
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