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Cysticidal activity of antifungals against different genotypes of Acanthamoeba

Alfonso Iovieno1, Darlene Miller2, Dolena R Ledee2

  • 1Bascom Palmer Eye Institute, University of Miami-Miller School of Medicine, Miami, Florida, USA Department of Ophthalmology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy alfonsoiovieno@hotmail.com.

Antimicrobial Agents and Chemotherapy
|July 9, 2014
PubMed

Insights

Antifungal drugs voriconazole and posaconazole show cysticidal activity against Acanthamoeba keratitis. This study identified effective treatments for this serious eye infection, regardless of Acanthamoeba isolate source.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis (AK) is a severe microbial keratitis.
  • Antifungal drugs are being explored as potential treatments for AK.

Purpose of the Study:

  • To evaluate the cysticidal activity of antifungal compounds against Acanthamoeba.
  • To determine if activity differs between clinical and culture collection isolates.

Main Methods:

  • Several antifungal drugs were tested.
  • Activity was assessed against various Acanthamoeba genotypes, including clinical and culture collection isolates.

Main Results:

  • Voriconazole and posaconazole demonstrated significant cysticidal activity.
  • No difference in antifungal activity was observed between clinical and culture collection isolates.

Conclusions:

  • Voriconazole and posaconazole are effective cysticidal agents against Acanthamoeba.
  • These antifungal drugs represent a promising therapeutic option for Acanthamoeba keratitis.

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