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Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple
Elçin Sehitoğlu1, Filiz Cavuş, Canan Ulusoy
1Department of Genetics, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
Objective:
To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS).
Methods:
Sera of 13 RIS patients were screened by a protein macroarray derived from human fetal brain cDNA library.
Results:
Sequencing of a clone with the highest signal intensity revealed sorcin as a potential target autoantigen in RIS patients. ELISA studies showed high-titer sorcin-antibodies in 3 of 4 RIS patients who converted to RRMS in a 5-year follow-up period and 13 of 23 control RRMS patients.
Conclusion:
The value of sorcin antibody as a predictor of conversion from RIS to RRMS requires to be tested in larger prospective studies.
