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Therapeutic vaccines for cancer: an overview of clinical trials

Ignacio Melero1, Gustav Gaudernack2, Winald Gerritsen3

  • 1Centro de Investigación Medica Aplicada (CIMA) and Clínica Universitaria (CUN), Universidad de Navarra, Spain.

Nature Reviews. Clinical Oncology
|July 9, 2014
PubMed

The therapeutic potential of host-specific and tumour-specific immune responses is well recognized and, after many years, active immunotherapies directed at inducing or augmenting these responses are entering clinical practice. Antitumour immunization is a complex, multi-component task, and the optimal combinations of antigens, adjuvants, delivery vehicles and routes of administration are not yet identified. Active immunotherapy must also address the immunosuppressive and tolerogenic mechanisms deployed by tumours. This Review provides an overview of new results from clinical studies of therapeutic cancer vaccines directed against tumour-associated antigens and discusses their implications for the use of active immunotherapy.

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