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Renal failure in a soldier taking N.O.-Xplode.

Kelly A Siano1

  • 1From the Department of Family Medicine, Tripler Army Medical Center, Honolulu, HI. ksiano1@gmail.com.

Journal of the American Board of Family Medicine : JABFM
|July 9, 2014
PubMed
Summary

A young man experienced severe kidney failure after taking the unregulated dietary supplement N.O.-Xplode. His kidney function recovered after stopping the supplement, highlighting risks of unregulated products.

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Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Dietary supplements lack US Food and Drug Administration (FDA) regulation.
  • Patient-physician communication regarding supplement risks is often inadequate.

Observation:

  • A 26-year-old man developed acute renal failure with flank pain after 3 months of N.O.-Xplode use.
  • Laboratory tests showed a creatinine level of 9.45 mg/dL.
  • Renal biopsy revealed acute tubular necrosis without glomerular abnormalities.

Findings:

  • No other cause for renal injury was identified.
  • Renal function normalized within one week of discontinuing N.O.-Xplode.
  • The supplement's ingredient list and safety data were unavailable.

Implications:

Keywords:
Case ReportsDietary SupplementsKidneysRenal Failure

Related Experiment Videos

  • This case underscores the potential for severe adverse events from unregulated dietary supplements.
  • Improved patient-physician dialogue is crucial for discussing supplement risks, efficacy, and FDA non-regulation.
  • Healthcare providers must counsel patients on the potential dangers of products with unknown ingredients and safety profiles.