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Updated: Aug 12, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
Deletion of C-reactive protein ameliorates experimental cerebral malaria?
Alexander J Szalai1, Scott R Barnum2, Theresa N Ramos3
1Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Background:
C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
Methods:
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
Results:
CRP-deficient mice were most resistant to ECM.
Conclusions:
CRP might contribute to the development of cerebral malaria, rather than protect against it.
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