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Safety of the nonionic contrast medium omnipaque in coronary angiography

K Levorstad1, K Vatne, U Brodahl

  • 1Department of Diagnostic Radiology, National Hospital, University of Oslo, Norway.

Cardiovascular and Interventional Radiology
|March 1, 1989
PubMed

Insights

The use of Omnipaque, a low osmolar nonionic contrast medium, in coronary angiography significantly reduced serious complications compared to older contrast agents. This study found fewer adverse events like myocardial infarction and cerebral embolism with Omnipaque.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Coronary angiography traditionally used high osmolar ionic contrast media.
  • These older agents were associated with a higher incidence of serious complications.

Purpose of the Study:

  • To evaluate the safety and efficacy of Omnipaque, a low osmolar nonionic contrast medium.
  • To compare complication rates of Omnipaque with historical data from high osmolar ionic media.

Main Methods:

  • A retrospective analysis of 5,339 consecutive coronary angiographies using Omnipaque.
  • Documentation and comparison of serious adverse events, including myocardial infarction, ventricular fibrillation, and cerebral embolism.

Main Results:

  • Omnipaque use was associated with a significant reduction in serious complications.
  • Specific events included myocardial infarction (4 patients, 2 deaths), ventricular fibrillation (1 patient), and cerebral embolism (11 patients, 0 deaths).

Conclusions:

  • Low osmolar nonionic contrast media like Omnipaque offer improved safety in coronary angiography.
  • The transition to nonionic media represents a significant advancement in reducing patient risk during cardiac procedures.

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