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Related Experiment Videos

Performance of a new transdermal nitroglycerin adhesive patch formulation.

D J Riedel1, K A Wick, R W Hawkinson

  • 1Hazleton Laboratories America, Inc., Madison, Wisconsin.

Clinical Therapeutics
|March 1, 1989
PubMed
Summary

A new nitroglycerin transdermal patch delivered 1.5 times more medication than ointment, based on surface area. This patch demonstrated effective nitroglycerin release and good skin adhesion over 24 hours.

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Area of Science:

  • Pharmacology
  • Dermatology

Background:

  • Nitroglycerin is used to treat angina.
  • Transdermal drug delivery offers potential advantages over oral administration.

Purpose of the Study:

  • To compare the transdermal absorption of nitroglycerin from a novel adhesive patch versus a conventional ointment.
  • To evaluate the pharmacokinetic parameters and delivery efficiency of the new nitroglycerin patch.

Main Methods:

  • A two-period crossover study involving 24 healthy men.
  • Comparison of a 20-cm2 nitroglycerin patch (q24hr) with 2% nitroglycerin ointment (q8hr) over a 50-cm2 area.
  • Analysis of plasma pharmacokinetic parameters and residual drug content.

Main Results:

  • The nitroglycerin patch delivered approximately 1.5 times more drug per unit surface area compared to the ointment.

Related Experiment Videos

  • Nitroglycerin release rate from the patch was determined to be 0.75 mg/cm2/24 hrs.
  • The transdermal patch demonstrated excellent skin adhesion throughout the 24-hour application period.

    • Conclusions:

    • The new nitroglycerin adhesive transdermal patch provides efficient drug delivery.
    • The patch is a viable alternative for transdermal nitroglycerin administration with improved delivery compared to ointment.
    • Further studies may explore the clinical efficacy of this new patch formulation.