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Histological-subtypes and anatomical location correlated in meningeal brain tumors (meningiomas)
Abdul Rashid Bhat1, Muhammed Afzal Wani1, Altaf Rehman Kirmani1
1Department of Neurosurgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Context:
Not enough literature is available to suggest a link between the histological subtypes of intracranial meningeal brain tumors, called 'meningiomas' and their location of origin.
Aim:
The evidence of correlation between the anatomical location of the intracranial meningiomas and the histopathological grades will facilitate specific diagnosis and accurate treatment.
Materials And Methods:
The retrospective study was conducted in a single high-patient-inflow Neurosurgical Center, under a standard and uniform medical protocol, over a period of 30 years from December 1982 to December 2012. The records of all the operated 729 meningiomas were analyzed from the patient files in the Medical Records Department. The biodata, x-rays, angiography, computed tomography (CT) scans, imaging, histopathological reports, and mortality were evaluated and results drawn.
Results:
The uncommon histopathological types of meningiomas (16.88%) had common locations of origin in the sphenoid ridge, posterior parafalcine, jugular foramen, peritorcular and intraventricular regions, cerebellopontine angle, and tentorial and petroclival areas. The histopathological World Health Organization (WHO) Grade I (Benign Type) meningiomas were noted in 89.30%, WHO Grade II (Atypical Type) in 5.90%, and WHO Grade III (Malignant Type) in 4.80% of all meningiomas. Meningiomas of 64.60% were found in females, 47.32% were in the age group of 41-50 years, and 3.43% meningiomas were found in children. An overall mortality of 6.04% was noted. WHO Grade III (malignant meningiomas) carried a high mortality (25.71%) and the most common sites of meningiomas with high mortality were: The cerebellopontine angles, intraventricular region, sphenoid ridge, tuberculum sellae, and the posterior parafalcine areas.
Conclusion:
The correlation between the histological subtypes and the anatomical location of intracranial meningeal brain tumors, called meningiomas, is evident, but further research is required to establish the link.
Insights
This study links meningioma location to tumor type, aiding diagnosis and treatment. Uncommon meningiomas often originate in specific brain areas, with malignant types showing higher mortality.
Area of Science:
- Neurosurgery
- Neuropathology
- Oncology
Background:
- Limited literature exists on the correlation between intracranial meningiomas' histological subtypes and their origin.
- Understanding this link is crucial for precise diagnosis and effective treatment strategies.
Purpose of the Study:
- To investigate the correlation between the anatomical location and histopathological grades of intracranial meningiomas.
- To provide evidence that facilitates specific diagnosis and accurate treatment of meningiomas.
Main Methods:
- A retrospective analysis of 729 operated meningiomas over 30 years (1982-2012).
- Evaluation of biodata, imaging (X-rays, CT scans, angiography), histopathological reports, and mortality data.
- Standardized medical protocol applied within a single high-inflow Neurosurgical Center.
Main Results:
- Uncommon meningioma subtypes (16.88%) were frequently found in the sphenoid ridge, posterior parafalcine, jugular foramen, cerebellopontine angle, and intraventricular regions.
- World Health Organization (WHO) Grade I meningiomas accounted for 89.30%, Grade II for 5.90%, and Grade III for 4.80%.
- Malignant (WHO Grade III) meningiomas showed a high mortality rate (25.71%), particularly in the cerebellopontine angles, intraventricular region, and sphenoid ridge.
Conclusions:
- A clear correlation exists between the histological subtypes and anatomical locations of intracranial meningiomas.
- Further research is warranted to solidify the established link between meningioma characteristics and their origin.
- The findings support the need for location-specific diagnostic and treatment approaches for meningiomas.
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