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Updated: Apr 27, 2026
06:47
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
8.8K
Vitamin D: relevance in dental practice
Francesco Saverio Martelli1, Marialaura Martelli1, Claudio Rosati1
1IRF in Microdentistry, Florence, Italy.
Summary
Genetic variations in the Vitamin D Receptor (VDR) gene are linked to periodontal disease susceptibility. VDR gene polymorphisms may influence bone metabolism and immune responses, impacting periodontal health.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Periodontal disease susceptibility is influenced by genetic factors.
- Vitamin D Receptor (VDR) gene variations are investigated for their role in immune and bone metabolism.
- Understanding VDR gene polymorphisms may offer insights into periodontal disease risk.
Purpose of the Study:
- To conduct a literature review on the association between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease.
- To explore the potential correlation between VDR gene variations and susceptibility to periodontal disease.
Main Methods:
- A systematic literature search was performed on PubMed.
- Keywords used were 'vitamin d receptor polymorphisms periodontal disease'.
- Included studies were clinical trials in humans, published in English.
Main Results:
- Evidence suggests a correlation between specific VDR polymorphisms and periodontitis.
- VDR gene variations may impact bone metabolism and immune responses relevant to periodontal health.
- Vitamin D's role in bone mineral density and immunomodulation is implicated in periodontal disease risk.
Conclusions:
- Specific VDR polymorphisms are associated with periodontitis and altered bone metabolism.
- Genetic screening for VDR variations can help identify patients at risk for decreased bone mineral density.
- Awareness of the VDR-periodontal health link can improve early osteoporosis detection and patient compliance.
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