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Updated: Apr 27, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in
Emanuela Ortolani1, Massimiliano Guerriero2, Antonella Coli3
1General Dentistry and Emergency Care Unit George Eastman Dental Hospital, Rome, Italy.
Abstract:
The ability of platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and platelet-rich plasma (PRP) to increase the rate of osseointegration of endosseous implants and to improve the quality of bone remodeling on the surface of titanium, has been investigated in an experimental intraosseous defect model by an histological and immunohistochemical evaluation. The results from this study demonstrate that rabbits treated with the combination PDGF/IGF-1 showed a higher positive effect on bone regeneration than PRP-treated or controls.
