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Updated: Apr 27, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Small fiber dysfunction in patients with Wilson's disease
Francisco de Assis A Gondim1, Davi F Araújo2, Italo S Oliveira2
1Departamento de Medicina Clínica, Serviço de Neurologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Objective:
Patients with Wilson's disease (WD) may develop a wide variety of neuropsychiatric symptoms, but there are few reports of autonomic dysfunction. Here, we described evidence of small fiber and/or autonomic dysfunction in 4 patients with WD and levodopa-responsive parkinsonism.
Method:
We reviewed the charts of 4 patients with WD who underwent evaluation for the presence of neuromuscular dysfunction and water-induced skin wrinkling test (SWT).
Results:
Two men and 2 women (33±3.5 years) with WD were evaluated. They all had parkinsonism at some point during their disease course. Parkinsonism on patient 4 almost completely subsided with treatment of WD. Two patients had significant sensory and 2 significant autonomic complaints, including syncopal spells. NCS/EMG was normal in all but SWT was abnormal in half of them (mean 4-digit wrinkling of 0.25 and 1).
Discussion:
A subset of patients with WD exhibit evidence of abnormal skin wrinkling test (small fiber neuropathy).
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