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Value of expression of insulin-like growth factor-1 receptor in gastric adenocarcinomas and normal gastric tissues

Ömer Topalak1, Funda Uğur Kantar, Çağnur Ulukuş

  • 1Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey. fundaugurkantar@yahoo.com.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|July 9, 2014
PubMed
Abstract

Insights

Insulin-like growth factor-1 receptor (IGF-1R) expression is significantly lower in gastric cancer tissues compared to normal tissues. This decreased IGF-1R expression correlates with lymph node metastasis, suggesting its role in gastric adenocarcinoma progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Insulin-like growth factor-1 receptor (IGF-1R) is crucial for cell growth and survival.
  • IGF-1R targeted therapies show promise in inhibiting cancer cell proliferation and inducing apoptosis.
  • Understanding IGF-1R expression in gastric adenocarcinoma is vital for developing targeted treatment strategies.

Purpose of the Study:

  • To compare IGF-1R expression levels between normal gastric mucosa and gastric adenocarcinoma tissues.
  • To investigate the correlation between IGF-1R expression and clinicopathological features such as tumor stage, differentiation, and lymph node metastasis in gastric cancer.

Main Methods:

  • Immunohistochemical analysis was employed to evaluate IGF-1R expression.
  • Expression levels were assessed semi-quantitatively in 47 gastric adenocarcinoma cases.
  • Paraffin-embedded tissues from normal and cancerous gastric specimens were utilized.

Main Results:

  • IGF-1R expression was significantly lower in cancerous gastric tissues (mean score 5.38) compared to normal tissues (mean score 8.40) (p<0.001).
  • A significant decrease in IGF-1R expression was observed in gastric cancer cases with lymph node metastasis compared to those without (p=0.035).

Conclusions:

  • Gastric adenocarcinoma tissues exhibit markedly reduced IGF-1R expression compared to normal gastric mucosa.
  • Metastatic progression in gastric cancer is associated with a gradual decline in IGF-1R expression.

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