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[Metabolism of L-thiazolidine-4-carboxylic acid]
S Böhler1, K Wagner, K H Bässler
1Physiologisch-Chemisches Institut, Johannes Gutenberg-Universität Mainz.
Infusionstherapie (Basel, Switzerland)
|April 1, 1989
Abstract:
L-thiazolidine-(4)-carboxylic acid (TAC) has proven to be a good substrate for long-term parenteral nutrition. In this study the metabolism of TAC in the rat is examined at subcellular level. TAC is oxidized by mitochondrial proline oxidase of liver and kidney to L-thiazoline-(4)-carboxylic acid, which then is hydrolyzed to N-formyl-cysteine (FCYS). FCYS is hydrolyzed to cysteine and formic acid by a cytosolic enzyme.