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Updated: Apr 27, 2026

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
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Effect of combining anesthetics in neonates on long-term cognitive function

Bradley H Lee1, Obhi D Hazarika1, Gabe R Quitoriano2

  • 1Department of Anesthesia and Perioperative Care, University of California San Francisco, United States.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|July 9, 2014
PubMed
Summary

Infant exposure to combined sevoflurane and nitrous oxide anesthesia impairs object recognition memory in adulthood. Sevoflurane alone did not affect cognitive development, indicating combined anesthetics uniquely impact long-term memory.

Keywords:
MemoryNeurotoxicitySevoflurane+/−nitrous oxideVolatile anesthetics

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