Related Experiment Video
Updated: Apr 27, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Long-term outcomes of drug-eluting versus bare-metal stent for ST-elevation myocardial infarction
Insights
Drug-eluting stents (DES) show no increased stent thrombosis risk compared to bare-metal stents (BMS) in ST-segment elevation myocardial infarction (STEMI) patients. DES may reduce reinfarction and lower long-term repeat revascularization needs.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Long-term outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in ST-segment elevation myocardial infarction (STEMI) patients are not fully understood.
- Uncertainty exists regarding the comparative safety and efficacy of DES and BMS in STEMI management.
Purpose of the Study:
- To investigate the long-term efficacy and safety of DES compared to BMS in patients with STEMI.
- To provide a comprehensive analysis of clinical outcomes following stent implantation in STEMI.
Main Methods:
- A systematic literature search was conducted across major databases (MEDLINE, EMBASE, Cochrane, Web of Science) up to February 2013.
- Randomized trials comparing DES and BMS in STEMI patients with over 12-month follow-up were included.
- Pooled estimates were calculated using risk ratios (RR) and 95% confidence intervals (CI) with a random-effects model.
Main Results:
- Ten trials involving 7,592 STEMI participants were analyzed.
- No significant difference in all-cause death or definite/probable stent thrombosis was observed between DES and BMS.
- DES showed a trend towards lower 1-year recurrent myocardial infarction (RR=0.75) and consistently reduced target vessel revascularization (TVR) (p < 0.01).
- Everolimus-eluting stents (EES) subgroup analysis indicated a reduced risk of stent thrombosis (RR=0.37, p=0.02).
Conclusions:
- Drug-eluting stents do not elevate stent thrombosis risk in STEMI patients compared to bare-metal stents.
- DES implantation is associated with a lower long-term risk of repeat revascularization and may decrease the incidence of reinfarction in STEMI patients.
Background:
Long-term outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) remain uncertain.
Objective:
To investigate long-term outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI).
Methods:
We performed search of MEDLINE, EMBASE, the Cochrane library, and ISI Web of Science (until February 2013) for randomized trials comparing more than 12-month efficacy or safety of DES with BMS in patients with STEMI. Pooled estimate was presented with risk ratio (RR) and its 95% confidence interval (CI) using random-effects model.
Results:
Ten trials with 7,592 participants with STEMI were included. The overall results showed that there was no significant difference in the incidence of all-cause death and definite/probable stent thrombosis between DES and BMS at long-term follow-up. Patients receiving DES implantation appeared to have a lower 1-year incidence of recurrent myocardial infarction than those receiving BMS (RR = 0.75, 95% CI 0.56 to 1.00, p= 0.05). Moreover, the risk of target vessel revascularization (TVR) after receiving DES was consistently lowered during long-term observation (all p < 0.01). In subgroup analysis, the use of everolimus-eluting stents (EES) was associated with reduced risk of stent thrombosis in STEMI patients (RR = 0.37, p=0.02).
Conclusions:
DES did not increase the risk of stent thrombosis in patients with STEMI compared with BMS. Moreover, the use of DES did lower long-term risk of repeat revascularization and might decrease the occurrence of reinfarction.
More Related Videos
11:01Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
Published on: September 18, 2015
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
Related Concept Videos
01:30Acute Coronary Syndrome I: Introduction
01:27Coronary Artery Disease V: Interprofessional Care
01:28Acute Coronary Syndrome IV: Interprofessional Care