Related Experiment Video
Updated: Apr 27, 2026
07:57
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
3.0K
[A neonate with umbilical cord bleeding].
Daphne P M de Wijs-Meijler1, Marc H Jonkers, A A M Ton Ermens
1Amphia Ziekenhuis, Breda.
Nederlands Tijdschrift Voor Geneeskunde
|July 10, 2014
Summary
A neonate experienced umbilical stump bleeding due to a rare factor XIII-deficiency. Prompt treatment with fresh frozen plasma successfully stopped the hemorrhage, highlighting the importance of timely diagnosis and intervention for this bleeding disorder.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Coagulation Disorders
Background:
- Umbilical stump bleeding in neonates can indicate underlying hemostatic abnormalities.
- Hyperbilirubinemia secondary to cephalic hematoma suggests potential birth trauma or coagulopathy.
Observation:
- A 7-day-old neonate presented with significant umbilical stump bleeding.
- Initial management involved fresh frozen plasma transfusion, which effectively controlled the hemorrhage.
Findings:
- Comprehensive coagulation testing revealed a deficiency in coagulation factor XIII.
- Factor XIII deficiency is a rare inherited bleeding disorder, often presenting with bleeding from the umbilical stump.
Implications:
- This case underscores the necessity of thorough coagulation evaluation in neonates with unexplained bleeding.
- Early diagnosis and management of factor XIII deficiency are crucial to prevent severe complications.
- Highlights the role of fresh frozen plasma in managing factor XIII deficiency in the neonatal period.
