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Published on: January 25, 2017
The molecular basis of IL-10 function: from receptor structure to the onset of signaling
1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA, walter@uab.edu.
Abstract:
Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.
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