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Cortico-striatal-thalamic network functional connectivity in hemiparkinsonism
Federica Agosta1, Francesca Caso1, Iva Stankovic2
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Neurobiology of Aging
|July 10, 2014
Summary
Functional connectivity in Parkinson's disease is altered in the cortico-striatal-thalamic network. Levodopa (L-dopa) treatment modulates these changes, potentially aiding compensation.
Area of Science:
- Neuroscience
- Neurology
- Systems Neuroscience
Background:
- Cortico-striatal-thalamic network dysfunction is implicated in Parkinson's disease (PD).
- The impact of levodopa (L-dopa) on this network's functional connectivity (FC) in hemiparkinsonism remains incompletely understood.
Purpose of the Study:
- To investigate cortico-striatal-thalamic network functional connectivity (FC) in hemiparkinsonism.
- To examine the relationship between FC and levodopa (L-dopa) treatment status and motor disability.
Main Methods:
- Functional connectivity (FC) analysis was performed on 69 patients with hemiparkinsonism (25 drug-naïve [n-PD], 44 treated [t-PD]) and 27 controls.
- FC patterns were compared across groups and correlated with motor severity.
Main Results:
- Drug-naïve PD patients exhibited increased basal ganglia FC and decreased connectivity in affected areas (caudate, thalamus) with cortical regions.
- Treated PD patients showed decreased striatal/thalamic FC but increased connectivity with temporal, parietal, and sensorimotor regions.
- Greater motor disability correlated with increased striatal/thalamic FC with posterior and cerebellar regions.
Conclusions:
- Hemiparkinsonism involves cortico-striatal-thalamic functional abnormalities that precede contralateral motor symptoms.
- Levodopa (L-dopa) modulates these abnormalities, potentially facilitating compensation through increased thalamic FC.
Keywords:
Cortico-striatal-thalamic networkHemiparkinsonismParkinson's disease (PD)Resting state functional MRI (RS fMRI)More Related Videos
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