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[Ovulation induction using clomiphene and human gonadotropins in combined therapy]
Jugoslavenska Ginekologija I Perinatologija
|January 1, 1989
Summary
This study combined clomiphene therapy and human gonadotropins to stimulate ovulation in 14 females. The combined therapy successfully induced ovulation in 20 cycles, leading to 11 pregnancies, demonstrating its efficacy in overcoming prior clomiphene resistance.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
Context:
- Ovulation induction is a key component of infertility treatment.
- Clomiphene citrate is a common first-line ovulation induction agent.
- Human gonadotropins are potent ovulation induction agents used when clomiphene fails.
Purpose:
- To evaluate the efficacy of a combined ovulation stimulation protocol using clomiphene citrate and human gonadotropins.
- To assess pregnancy outcomes in patients with a history of failed ovulation induction with clomiphene alone.
Summary:
- A combined ovulation stimulation protocol involving clomiphene citrate and human gonadotropins was administered to 14 infertile females over 21 cycles.
- Ovulation was monitored using cervical score, ultrasonic folliculometry, cervical mucus quality, basal body temperature, and serum progesterone.
- Ovulation was successfully induced in 20 of 21 cycles, resulting in 11 pregnancies (6 term deliveries, 2 ectopic, 1 spontaneous abortion, 1 missed abortion, 1 blighted ovum), and 2 twin pregnancies.
Impact:
- The combined therapy proved effective in inducing ovulation and achieving pregnancy in patients resistant to clomiphene citrate monotherapy.
- This approach offers a viable treatment option for specific infertility cases, with a manageable safety profile (one case of mild hyperstimulation syndrome).
- The study contributes to optimizing ovulation induction protocols for improved fertility outcomes.