Related Experiment Video
Updated: Apr 27, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
Antiepileptic drugs for neuropathic pain and fibromyalgia
Andrew Moore1, Philip Wiffen1, Eija Kalso2
1Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
Clinical Question:
Are antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?
Bottom Line:
In treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.
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