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B-acute lymphoblastic leukaemia.

Rashmi Kushwaha1, Ashutosh Kumar1, Mili Jain1

  • 1Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India.

BMJ Case Reports
|July 10, 2014
PubMed
Summary
This summary is machine-generated.

A rare presentation of B-acute lymphoblastic leukemia (B-ALL) in a child included skeletal pain, high calcium, and bone lesions. This case highlights the importance of considering B-ALL in pediatric patients with unexplained bone abnormalities and hypercalcemia.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Skeletal Pathology

Background:

  • B-acute lymphoblastic leukemia (B-ALL) is a common childhood cancer.
  • Typical B-ALL presentations involve symptoms like fatigue, bruising, and infections.
  • Rarely, B-ALL can manifest with skeletal abnormalities and hypercalcemia.

Observation:

  • A 13-year-old boy presented with fever, bone pain, increased thirst and urination, and multiple osteolytic lesions in the pelvis and femur.
  • Elevated serum calcium levels were noted.
  • Bone marrow examination revealed blast cells, confirmed as B-ALL via flow cytometry.

Findings:

  • The patient was diagnosed with B-acute lymphoblastic leukemia (B-ALL).
  • Hypercalcemia and osteolytic bone lesions are identified as uncommon presenting features of B-ALL.
  • No organomegaly or lymphadenopathy was observed.

Implications:

  • Clinicians should consider B-ALL in the differential diagnosis for children presenting with unexplained skeletal pain and lytic bone lesions.
  • Early recognition of rare B-ALL presentations is crucial for timely diagnosis and treatment.
  • This case broadens the understanding of B-ALL's diverse clinical manifestations in pediatric patients.