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Related Experiment Video

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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Preimplantation genetic screening: back to the future.

Sebastiaan Mastenbroek¹, Sjoerd Repping²

¹Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Q3-119, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands s.mastenbroek@amc.uva.nl.

Human Reproduction (Oxford, England)

|July 10, 2014

Summary

Preimplantation genetic screening (PGS) adoption led to higher costs and lower effectiveness. Current advancements question if this new era of PGS offers genuine improvement or repeats past mistakes.

Keywords:

IVF/ICSI PGS aneuploidy efficacy randomized controlled trials

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Last Updated: Apr 27, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Area of Science:

Reproductive medicine
Genetics
In vitro fertilization

Background:

Past adoption of preimplantation genetic screening (PGS) using cleavage stage biopsy and fluorescence in situ hybridization (FISH) lacked cost-effectiveness evaluation.
This led to increased patient expenses and reduced treatment efficacy.

Purpose of the Study:

To evaluate the evolution and current state of preimplantation genetic screening (PGS).
To determine if recent advancements in PGS represent a true improvement or a recurrence of past issues.

Main Methods:

Review of historical data and clinical practices regarding PGS.
Analysis of current technological advancements and their implementation in genetic screening.

Main Results:

Initial widespread adoption of PGS without efficacy and cost-effectiveness studies proved detrimental.
Current trends in PGS suggest a potential for repeating previous suboptimal outcomes.

Conclusions:

The history of PGS highlights the critical need for rigorous evaluation before clinical implementation.
Ongoing advancements necessitate careful assessment to ensure improved patient outcomes and cost-effectiveness.