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Updated: Apr 27, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
Preimplantation genetic screening: back to the future
Sebastiaan Mastenbroek1, Sjoerd Repping2
1Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Q3-119, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands s.mastenbroek@amc.uva.nl.
Abstract:
All agree that in hindsight the rapid adoption of preimplantation genetic screening (PGS) using cleavage stage biopsy and fluorescence in situ hybridization (FISH) in routine clinical practice without proper evaluation of (cost-)effectiveness basically resulted in couples paying more money for a less effective treatment. Now, almost 20 years later, we are on the verge of a new era of PGS. But have things really changed or are we simply going back to the future?

