Related Experiment Video
Updated: Apr 27, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
MicroRNAs in right ventricular (dys)function (2013 Grover Conference series)
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany ; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College London, London, United Kingdom.
MicroRNAs (miRNAs) are crucial for heart health. This review explores their role in the right ventricle, offering insights into new diagnostic and therapeutic strategies for right heart diseases like pulmonary hypertension.
Area of Science:
- Cardiology
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) are vital regulatory molecules with established roles in the left ventricle.
- Information regarding miRNA expression, regulation, and function in the right ventricle remains limited.
- Right heart diseases, particularly pulmonary hypertension, significantly impact patient outcomes.
Purpose of the Study:
- To comprehensively review the current understanding of microRNAs in right heart diseases.
- To discuss emerging therapeutic strategies involving miRNA modulators for pulmonary hypertension and right ventricular dysfunction.
- To present the diagnostic and predictive potential of circulating miRNAs in patients with these conditions.
Main Methods:
- Literature review of existing research on miRNAs in cardiovascular contexts.
- Analysis of studies focusing on miRNA expression and function in the right ventricle.
- Examination of clinical trials and research on miRNA-targeted therapies and biomarkers.
Main Results:
- miRNAs play a significant role in the development and progression of right heart diseases.
- miRNA modulators show promise as therapeutic agents for pulmonary hypertension, improving right ventricular function.
- Circulating miRNAs are potential biomarkers for diagnosing and predicting outcomes in patients with right ventricular failure.
Conclusions:
- Increased knowledge of right heart miRNAs is essential for advancing treatment strategies.
- Targeting miRNAs offers a promising avenue for novel therapies in pulmonary hypertension and right ventricular disease.
- Circulating miRNAs hold potential for improved diagnostics and prognostics in right heart conditions.
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07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
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