Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts

Area of Science:

• Pharmacology
• Ethnobotany
• Plant-based medicine

Background:

• Ficus glomerata is a traditional medicinal plant.
• Investigating its therapeutic properties is crucial.

Purpose of the Study:

• To evaluate the thrombolytic and antimitotic potential of Ficus glomerata fruit extracts.
• To compare the efficacy of petroleum ether, chloroform, and methanol extracts.

Main Methods:

• In vitro thrombolytic assay using streptokinase as a standard.
• In vitro antimitotic assay evaluating root growth inhibition and mitotic index.
• Preparation of crude extracts: petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME).

Main Results:

• Methanolic extract (FGME) showed significant thrombolytic activity (47.74% clot lysis), outperforming FGPE and FGCE.
• Streptokinase (standard) achieved 74.22% clot lysis.
• FGME demonstrated the most effective antimitotic activity, inhibiting root growth and impacting the mitotic index, followed by FGPE.

Conclusions:

• Ficus glomerata fruit extracts possess notable thrombolytic and antimitotic properties.
• The methanolic extract exhibits the highest potential for both activities.
• Further research into Ficus glomerata could lead to novel therapeutic agents.